Director, Project Toxicologist, Safety Sciences China
At AstraZeneca, we push the boundaries of science to deliver life-changing medicines. Our global Safety Sciences organization delivers innovative non-clinical safety science and toxicologyexpertiseto enable the discovery,developmentand registration of novel medicines.
We areseekinga highly motivatedDirector, Project Toxicologist,to join ourSafety Sciences Chinagroup.This role willbring non-clinical safetyexpertiseand effectivediscovery and regulatorytoxicology strategies todelivernew candidate drugprojects(internally and/or with collaborators),ensuringlocalpreclinical safety input that integrates seamlessly into global development and submissions.
Youwillpartner withglobalcross-functional teams acrosstherapeutic areasand modalities(small molecules, radio-conjugates,immune-cell engagers,antibody–drug conjugates,peptides,etc).
Job description
Lead regulatory and investigative toxicology study design, developing strategies to predict, assess, and mitigate target- and modality-related safety risks.
Apply your toxicology expertise to predict clinical safety risks and, ascore member of drug project teams,support data-driven decisions across discovery and development programs.
Provide strategic toxicology input for in-licensing evaluations and external collaborations.
Communicate integrated risk assessments to governance bodies and contribute to regulatory submissions.
Maintain and expandexpertisein regulatory standards, preclinical safety, and modality-specific safety science, staying ahead of industry trends.
Innovate at the intersection of regulatory toxicology andcutting-edgescience,leveragingin vitro, in silico, in vivo, and emerging technologies like organ-on-chip, imaging, and omics, and contribute to internal and external scientific reputationthrough internal and external collaborations, publications, and thought leadership.
Role model demonstration of AZ Values.
Essential skills and experience
PhD and/or DABT in Toxicology, Pharmacology,Cell Biology,Pathologyor related field,with a strong scientifictrack record(or another university degree withrelevant work experience).
Robustexperience in Project Toxicology, Investigative Toxicology, or relatednon-clinicalsafety-focused roles in pharma, biotech, or CRO environments.
Deep understanding of drug discovery and development, with proven ability to deliver toxicology programs supporting IND filings.
Expertiseacross small and large molecule modalitiesand relevant therapeutic areas (e.g.Oncology, Cardiovascular, Metabolism, Immunology, Respiratory).
Excellent communication, interpersonal, and influencing skills to inform decisions across scientific and regulatory teams.Fluency in English and Mandarin is essential. Strong awareness of work-related cultural aspects across China, EU, UK,USand a proven ability to work across geographies and cultural barriers, building trust and effective collaboration in a global pharma environment.
Skilled inusing invitro, in silico, and in vivo tools to predict clinical safety risks.
Collaborative, problem-solving mindset with the ability to coordinateand prioritizeacross multiple projects.
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
