Head of Pharmacometrics

Qualifications

• PhD in quantitative disciplines such as pharmacometrics, pharmacology, mathematics and statistics
• Proficient skills with R and NONMEM (both essential) for modeling and simulation (M&S) work; and other software, e.g., MATLAB, Monolix, etc.; and experience and knowledge in constructing mechanistic or mechanism-based models
• Excellent knowledge of pharmacokinetics [PK], pharmacodynamics [PD], development and regulatory science and other areas (biology, medicine, etc.)
• Research experience and interest with advanced technologies such as AI/ML preferred
• Publications in peer-reviewed journals in pharmacometrics areas

Responsibilities

• Manage all business of pharmacometrics (PM) group; drive implementation of model-informed drug development concepts to support optimal dose/dosing regimen selection; clear strategic thinking and people leadership
• Support PM members for routine M&S work including translational/mechanism-based modelling activities for mechanistic understanding of different targets and modalities and population PK-PD and dose-exposure-response analyses for drug NDA submission or internal decision making
• Communicate with cross-functional teams for model interpretations, modeling ideas and results
• Provide pharmacometrics input in regulatory documents (e.g., briefing book, IND/NDA)
• Prior, adequate people management experience is needed with a passion to develop people
• Guide and train junior members

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.