Senior/ Principal/AD Pharmacometrician

Recognised as expert own area and often seen as point of reference for others in R&D China teams.

Qualifications

• PhD in quantitative disciplines such as pharmacometrics, pharmacology, mathematics and statistics
• Proficient skills with R and NONMEM (both essential) for modeling and simulation (M&S) work; and other software, e.g., MATLAB, Monolix, etc.; and experience and knowledge in constructing mechanistic or mechanism-based models
• Working knowledge of other areas (pharmacokinetics [PK], pharmacodynamics [PD], biology, medicine, development and regulatory science, etc.)
• Research experience and interest with advanced technologies such as AI/ML preferred
• Publications in peer-reviewed journals in pharmacometrics areas preferred

Responsibilities

• Perform routine M&S work to support drug development projects based on e.g. CDE guidance of model-informed drug development (MIDD); a senior level is expected to drive implementation of MIDD concepts to support optimal dose/dosing regimen selection
• Conduct population PK-PD, dose-exposure-response analyses to support drug NDA submission; a senior level hire is expected to drive such analysis work including translational/mechanism-based modelling activities for mechanistic understanding of drug candidates of different targets and modalities
• Communicate with cross-functional teams for model interpretations, modeling ideas and results
• Provide pharmacometrics input in regulatory documents (e.g., briefing book, IND/NDA)
• Guide and train junior members
• If people manager hire, then prior, adequate people management experience is needed with a passion to develop people; clear strategic thinking and people leadership are also necessary

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. 
阿斯利康是一家提供平等机会的企业，我们将考虑所有符合条件的求职者就业。不因残疾、性别或性取向、怀孕或产假状况、种族或民族或族裔出身、年龄、宗教或信仰、性别认同或变更、婚姻或伴侣关系、受保护的退伍军人身份（如果适用）及任何其他受法律保护的特征而产生歧视。

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.